Nepal is among the most climate change vulnerable countries in the world due to its high exposure and sensitivity to climatic risks and hazards, and low adaptive capacity. The agricultural system of Nepal that generates 66% employment is highly affected by frequent droughts, floods, heat waves, cold waves, and changes in the onset and duration of the monsoon. Women and poor farmers are at risk of food insecurity along with increased drudgery in farming due to these challenges. To sustain agricultural contribution to national GDP, employment, and food security, new and innovative strategies must be put in place to reduce the impacts with low carbon development measures. Climate-Smart Agriculture (CSA) can be the way forward.